ASU is at the forefront in describing the molecular basis of disease and critical protein/drug interactions with atomic-scale resolution. We are developing sensors for the early detection of disease, using biophysics and novel analytics for disease diagnosis at the atom, molecule and cell level, designing new drugs that target specific metabolic pathways, and are building high-throughput diagnostic arrays for personalized medicine.
Faculty
Earth Surface Chemistry, Mass Spectrometry, Isotopic Composition Studies, Biogeochemistry
Analytical biochemistry, mass spectrometry, protein posttranslational modifications, disease markers
Structure, function and evolution of ribonucleoprotein complexes, RNA-protein interactions, telomerase biogenesis and mechanism
electron microscopy, cryo-EM, electron crystallography, membrane protein, structural biology, signal processing, image processing
Structural biochemistry and biophysics, membrane proteins, X-Ray crystallography, photosynthesis, molecular biology
Microfluidics, bioassays, microchip devices, Noninvasive sampling, materials and surface chemistry
Molecular modeling, biomolecular interactions and solvation, intermolecular vibrations, molecular crowding, complex formation and self-assembly
Biomolecular structure, dynamics, interactions and functions. Translational research
Structure and function of nucleoprotein complexes; bacterial immune systems; CRISPR-Cas; RNA modifications; engineering genome editing tools
Scanning probe microscopy, molecular electronics, molecular biophysics, nano-scale self-assembly
Micro and nanofluidics Bioanalytics, Single cell analysis, Biomolecule migration mechanisms
Molecular dynamics simulations, Cryo-electron microscopy, X-ray crystallography, hybrid modeling
Coarse-grained modeling of DNA and RNA with applications to DNA/RNA nanotechnology, RNA folding, Molecular simulations to study properties of DNA and RNA in vivo and in vitro, Applications of statistical physics modeling to complex systems
Membrane proteins, Solution NMR, Structural biology, Biophysical Chemistry, Enzymology, Electrophysiology, Computational structural biology, Ion channels, Membrane enzymes
Biochemistry, NMR, protein, carbohydrate, glycan, glycosaminoglycan, protein structure, protein-carbohydrate interactions
Design and assembly of biologically inspired nanomaterials, DNA nanostructures, nanoelectronics, biomolecular imaging